Nanoknife

Pancreatic cancer, a cancer with high degree of malignancy, is a kind of malignant digestive tumor of difficulty diagnosis and treatment, which about 90% of them are originated from ductal adenocarcinoma. Moreover, accurate diagnosis is difficult and with a very high operative mortality and a low cure rate. It can achieve certain effects with physical ablation therapy while conventional chemotherapy and radiotherapy can just have a limited overall effect. Unfortunately, due to the characteristic of pancreas, using recent ablation therapy to deal with pancreatic cancers still has high complication rate and mortality.

Currently, the complication rate of radiofrequency ablation for the treatment of pancreatic cancers is about 28％-40％, and the mortality is 7.5%. Now, the three problems of pancreatic cancer physical ablation therapy are uncomprehensive ablation, blood vessel damaged and intestine wall and pancreatic duct injured, which can be greatly solved by nanoknife with the advantages of killing cancer cells by damage cancer cell construction by electrical current, without any injure on important organizations such as blood vessels, intestinal canal and nerve. Referring to the study from American Surgical Association, most of the pancreatic cancer patients can have double survival rate.[More]

Nanoknife for pancreatic cancer was performed successfully in St. Stamford Modern Cancer Hospital Guangzhou. Li Xingde (alias), from Indonesia, was diagnosed with pancreatic cancer stage 3, tumor size of 4.5 × 4cm. Due to rather special anatomical position of the pancreas, pancreatic surgery is of high risk and no radical resection. Moreover, chemotherapy and radiation has limited treatment effect on pancreatic cancer. In this case, advantages of Nanoknife perfectly make up the short boards of pancreatic cancer treatment. Nanoknife is to destroy cancer cell membrane structure by using of electric current, leading to cell death, without damaging surrounding tissues such as blood vessels, bowel, and nerves. After a joint consultation over his case, MDT of MCHG decides to adopt the most advanced Nanoknife for him.

Advantages of Nanoknife

1.Short ablation duration

2.Safe and controllable treatment process

3.Distinct border of ablation area

4.Reservation of vein, nerve and other normal tissues

5.Rapid recovery of ablation zone6.Adaptable to more complicated condition

How does Nanoknife work?

Step 1: Release high voltage pulses from electrode probes

Step 2: Break through tumor cells, resulting in multiple permanent nano-meter irreversible electroporation

Step 3: Damage membrane of tumor cells

Step 4: Accelerate death of cancer cells

Step 5: Phagocytes of human body eliminate the dead tissues

Nanoknife therapy is suitable for these patients:

1. Early, middle and advanced stage cancer patients;

2. Patients unsuitable or unwilling to undergo surgery or chemotherapy;

3. Relapsing cancer patients who cannot tolerate surgery again;

4. Conventional treatments performed patients who show limited effects;

5. Tolerability and adverse reactions showed patients for chemotherapy.

Who is forbidden for nanoknife?

1. Patients with existence of implanted pacemaker or defibrillator within ablation region

2. Patients with implanted electronic equipment and metal parts near the ablation region

3. Lesion of eyes, including the eyelids

4. Patients with a medical history of seizures or cardiac arrhythmias

5. Patients have myocardial infarction recently.